Lab handlingReceiving Temperature-Sensitive Shipments: A Lab Checklist
A practical receiving checklist for cold-chain research materials, from reading temperature indicators to logging receipt and documenting excursions.
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Lab handling
Analytical methodsLC-MS vs MALDI-TOF for Peptide Identity Confirmation
A side-by-side look at ESI LC-MS and MALDI-TOF for confirming peptide identity: ionization, charge states, mass accuracy, sample preparation, adducts and typical uses.
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Analytical methodsPeptide Hydrophobicity in HPLC: Retention and Peak Shape
How amino acid sequence drives reversed-phase retention, how to choose gradients, columns and ion-pairing agents, and how to troubleshoot broad, tailing or split peptide peaks.
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Analytical methodsConfirming Peptide Identity by Mass Spectrometry
How ESI and MALDI mass spectrometry confirm that a research peptide is the intended molecule.
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Lab handlingHandling Lyophilized Powders: PPE, Weighing and Spills
How to open, weigh and clean up fine lyophilized powders safely, with practical fixes for static, drafts and secondary container labeling.
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Analytical methodsAmino Acid Analysis for Peptide Quantitation Explained
A walkthrough of amino acid analysis: hydrolysis, derivatization chemistries, separation, a worked net peptide content example and the residues that need special handling.
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Analytical methodsKarl Fischer Water Content Testing for Lyophilized Peptides
Volumetric and coulometric Karl Fischer titration compared, why water matters for lyophilized materials, how to handle hygroscopic samples and how results appear on a COA.
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Analytical methodsSynthetic Peptide Impurities: How They Show in HPLC and MS
Deletion sequences, protecting-group adducts, oxidation, deamidation, racemization and aggregation: where each impurity comes from and how to spot it in HPLC and MS.
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Analytical methodsHPLC Purity Testing Explained
How reversed-phase HPLC measures peptide purity, what the percentage means, and how to read a chromatogram.
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Lab safetySafety Data Sheet Sections: A Guide to All 16 Under GHS
Where to find hazards, storage, PPE, spill and disposal information in a 16-section GHS safety data sheet, and how OSHA HazCom applies in the lab.
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Peptide chemistryPeptide Counter-Ions: TFA, Acetate and HCl Salt Forms
Why synthetic peptides carry trifluoroacetate, how acetate and chloride exchange work, and how counter-ions affect weighed mass, assays and documentation.
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Lab handlingLyophilized Cake Appearance: What It Can and Can't Tell You
How to inspect a freeze-dried vial: what normal looks like, what collapse, meltback, shrinkage and cracking mean, and why appearance never replaces analytical testing.
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