DocumentationHow to Read a Certificate of Analysis (COA)
What each section of a research peptide certificate of analysis tells you, and how to match it to the vial on your bench.
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Documentation
Quality systemsResearch Peptide Supplier Qualification: A Checklist
The documents to request, questions to ask and red flags to watch for when qualifying a research peptide supplier.
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Analytical methodsHPLC System Suitability and Reference Standards Explained
What reference standards are and how HPLC system suitability checks such as resolution, tailing, plate count and repeatability make results trustworthy.
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Lab safetyLaboratory Chemical Waste Disposal: Core Principles
General principles for segregating, labeling and accumulating lab chemical waste, and why your institutional EHS office and local rules have the final word.
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Quality systemsLot Traceability in Research Supply: Vial to COA
How lot numbers connect a vial to its packing slip, COA and production records, and how labs and suppliers use traceability when issues arise.
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Contaminant testingResidual Solvents in Synthetic Peptides: Headspace GC and USP <467>
Why solvents can remain after peptide synthesis, how headspace gas chromatography measures them, and how ICH Q3C classes are used.
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Analytical methodsAnalytical Method Validation: An ICH Q2(R2) Guide
A practical walk through the ICH Q2(R2) validation characteristics and how to interpret “validated method” on a certificate of analysis.
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Contaminant testingBioburden vs Sterility vs Endotoxin: What Each Test Means
Bioburden, sterility and endotoxin answer three different microbiological questions. Here is what USP <61>, <71> and <85> each measure.
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DocumentationALCOA+ Data Integrity: A Practical Guide for Labs
What each ALCOA+ principle means in practice, with paper and electronic examples, audit trail basics and a checklist for research labs.
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Contaminant testingElemental Impurities Testing: ICP-MS and USP 232/233
How USP <232>/<233> and ICH Q3D shape elemental impurities testing, how ICP-MS and ICP-OES compare, and how to read element results on a COA.
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Contaminant testingBacterial Endotoxin Testing: LAL Methods and USP <85>
What endotoxins are, why they matter in cell-based research, and how gel-clot, turbidimetric and chromogenic LAL assays measure them.
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Analytical methodsPeptide MS/MS Sequencing: b/y Ions and Peptide Mapping
How tandem mass spectrometry reads a peptide sequence from b and y fragment ions, how peptide mapping works, and what MS/MS can and cannot distinguish.
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